Primary central nervous system lymphomas (PCNSL) are rare and aggressive type of non Hodgkin lymphomas which form about 2–3% of all CNS tumors.

We undertook a retrospective study of PCNSL at our Institute over a period of 6 years, wherein the clinical and immunomorphological features of PCNSL were studied.

 There were 27 cases of PCNSL, males were more commonly affected with an age range of 12–68 years. Almost all were B cell lymphomas and diffuse large B cell lymphoma (DLBCL) was the commonest type, with most showing centroblastic morphology. Further subtyping into germinal centre B cell(GCB) and non germinal centre B cell(NGCB) groups by IHC was possible in 18 cases using Hans algorithm, which showed higher number of  NGCB cases. There were one case each of anaplastic large cell lymphoma and follicular lymphoma.