Background: Gutta Flow and Real Seal are sealers or adjunct to core obturating materials used in the obturation of root canals.

Objective: To compare the area of sealer and voids in root canals obturated with Gutta Flow and Real Seal .

Material and Methods: Forty premolars were decoronated, cleaned and shaped. Obturation was done with Gutta–Percha using Real Seal and Gutta Flow as sealers. Comparision of the area of sealers and voids were done.

Results: Comparision of gutta–percha/GuttaFlow to gutta–percha/Epiphany yielded a statistical significant difference between the two groups for both the variables (p = 0.000000094 and p = 0.000059202).

Conclusion: Real Seal as a sealer used in obturation of root canals yields better outcomes.