AIM: To study the various clinical manifestation and complication of Sickle cell syndrome along with laboratory features.

METHODS: Patients with sickle cell syndrome admitted in RIMS , Ranchi were studied using random sampling method over a period of one year. Complete blood count, sickling test, Bone Marrow Examination, High performance liquid chromatography investigation were done to find out the result.

RESULT: The prominent clinical manifestation of sickle cell syndrome were yellowish discoloration of sclera, pain abdomen, fatigue, followed by fatigue and fever and then combination of fever and bodyache. In the study we found 15 cases of sickle cell disease presented with vasooclusive crises, 4 patient with sequestration crisis and 2 patient with acute chest syndrome. In the laboratory parameters we found a significant correlation between hemoglobin S and serum iron and serum potassium with a p value of 0.001 and 0.035 respectively, most of the cases of sickle cell disease are associated with hypoxia with poa2 approximately 85mmhg whereas those with sickle cell trait had poa2 in the normal range.

CONCLUSION: Yellowish discoloration of sclera was the most prominent clinical manifestation and vasooclusive crisis was the most common complication of sickle cell disease. There was a significant correlation between hemoglobin s and serum iron and serum potassium.