In this article, the results of a study, conducted in 200 patients with confirmed rheumatoid arthritis and 30 controls, tested for the ESR, CRP, RF, anti–CCP and anti–MCV biomarkers, are presented. The results for the sensitivity, specificity, positive and negative predictive values of the studied tests are presented. The obtained results show higher diagnostic sensitivity and specificity of the anti–CCP and anti–MCV tests. The combination of the two biomarkers, anti–CCP and anti–MCV, and the RF improves the diagnostic and prognostic value