BACKGROUND: Globally, depression is a highly prevalent psychiatric disorder and the leading cause of disability in adolescents. This study explores the prevalence of depression and its associated factors among young females in secondary schools in Al–Khobar City, Eastern Province, Saudi Arabia.

METHOD: A prospective cross–sectional study using multistage random sampling methodology was performed, specifically targeting the city’s secondary school girls. A self–administered questionnaire was distributed comprising three aspects: the collection of sociodemographic data and the application of MSPSS and BDI2.

RESULT: The prevalence of depression was found to be 23.8%, with significant association detected between age, academic performance, and level of social support; 17.4%, 3.8%, and 2.6% of the respondents reported having mild, moderate, and severe depression, respectively.

CONCLUSION: Depression in adolescence should not be underestimated. Early screening to identify depression is required for early diagnosis, treatment, and to plan preventive and‏ control strategies.