“Small Round Cell Tumours” are a group of highly aggressive malignant neoplasms which feature small and monotonous undifferentiated cells with high nuclear cytoplasmic ratio on histology. As the treatment and prognosis vary greatly among these tumors accurate conclusive diagnosis is essential.  A total of 76 cases were diagnosed as small round cell tumor on H&E stained section, which were further categorized using IHC profile. Final diagnosis of 88.16% cases of SRCT could be achieved on the basis of morphology and IHC evaluation, 75% cases required IHC for their subtyping while 25%could be accurately diagnosed on the basis of morphology and clinical corelation& 11.84% of cases remained unclassified.  Conclusion: Immunohistochemistry is a very useful diagnostic tool in differential diagnosis of small round cell tumours in conjunction with morphological features and clinical parameters.