Present study is a cross section, observational study to find out adverse drug reactions and efficacy of antipsychotic drugs used in schizophrenia and bipolar patients. This paper is only a part of my study with thesis topic “an observational study of adverse drug reactions of antipsychotic drugs in schizophrenic and bipolar disorder patients.” Total 77 patients were registered after taking written informed consent. PANSS scale used in scizophreina patients and this scale gives idea about patient improving on medication if score of scale is decreased.