Background: Genetically determined variation in salivary protein composition may play an important role in dental caries etiology and other oral diseases.

Aim: To evaluate the correlation between various salivary proteins and DMFT with the help of SDS–PAGE.

Materials and methods: Using standardized parameters, salivary samples were collected from 50 individuals, which were subjected to SDS–PAGE. Subsequently, the DMFT was correlated with various salivary proteins amongst other parameters like age, sex, diet etc.

Statistical Analysis: Chi square test was used to test the association of the two independent variables with p < 0.05 considered as significant.

Results: DMFT significantly increased (p value for, MG1<0.005, MG2<0.001 and PRP–1<0.048) with increasing age and reduction in the expression of salivary proteins.

Conclusion: DMFT was increased due to decrease in proteins (except myosin) and poor oral hygiene while DMFT increased due to increase in age.