Aim: Chronic kidney disease is an irreversible deterioration of renal function, which results from diminished effective functioning of renal tissue. Cardiovascular disease is a major cause of morbidity and mortality among patients with chronic kidney disease. More than 50 percent of patients with CKD die due to cardiovascular complications. The growing recognition that dyslipidemia is a major risk factor for coronary heart disease has prompted interest in the identification and management of abnormalities in plasma lipids and lipoproteins. The aim of this study is to investigate the pattern of lipid fraction according to ATPIII categorization in different stages of CKD patients. Design/Methods:  This is a comparative study and 100 subjects were categorized according to ATPIII categorization and National Kidney Foundation guidelines on staging of CKD patients. Results: An increased levels of triglycerides and VLDL levels were observed as the stage of CKD progressed, which was statistically significant too. HDL cholesterol level was found to be significantly lower in CKD patients as stages progressed. Total cholesterol, LDL and HDL levels decreased in CKD patients. Conclusions: We conclude that lipid abnormalities in the progression of the renal failure and predisposes to atherosclerosis, hence it is early detecting and treating the hyperlipidemia in CRF patients.