Oral Squamous Cell Carcinoma (OSCC) accounts for 90% of all oral cancers. It may affect any anatomical site in the mouth, but most commonly the tongue and the floor of the mouth. Regardless of the treatment modality and advances in diagnostic research and therapeutic sciences the survival rate is poor resulting in untimely death. The yeast–like fungus Candida albicans and a few other Candida species are capable of producing skin, mucous membrane, and internal infections. The exact pathologic significance of fungal, mainly the candidal infection is still unknown, but leukoplakia could be a potentially malignant oral mucosal lesion, and the Candida infection is generally accepted as the main etiologic factor for the occurrence of oral epithelial neoplasia. The present study was formulated to evaluate the presence of candidal hyphae in cases of potentially malignant disorders.