Background : Coagulase Negative Staphylococci are one of the most common pathogens isolated from nosocomial and community acquired infections.  High incidence of antibiotic resistance, in particular methicillin resistance has complicated the treatment of these infections. Clindamycin has been used successfully to treat the methicillin–resistant CoNS (MRCoNS) in adults and children, but this matter is complicated by the possibility of inducible macrolide–lincosamide streptogramin B resistance (MLSBi). The Aim of this study is to determine the antimicrobial susceptibility pattern – methicilin resistance, macrolides lincosamides–streptogramin B (MLSB) resistance and  multidrug resistance among CoNS isolates. Materials and Methods: A total of 135 consecutive, non–duplicate strains of CoNS, isolated from various clinical specimens were included in the study. After determining the susceptibility to different antimicrobial agents and methicillin resistance, D–test was performed on all erythromycin–resistant and clindamycin–sensitive isolates to detect constitutive and inducible clindamycin resistance. Results: Among135 CoNS isolates73 (54%) were found to be MRCoNS. MDR was also prevalent among CoNS isolates 58(43%) and the prevalence was more in the methicillin–resistant isolates (79%). MRCoNS showed higher inducible as well as constitutive resistance  to clindamycin as compared to methicillin–sensitive CoNS (MSCoNS). The CoNS isolates exhibited  32% MLSBi phenotype and 43%MLSBc phenotype . All isolates having MLSBi phenotype were sensitive to vancomycin and linezolid. Conclusions : Clindamycin is a useful drug in the treatment of staphylococcal infections. Hence, routine testing of staphylococcal isolates for inducible clindamycin resistance is strongly recommended.