Chemotherapy is one of the important modality to combat cancer in this era. The haematological changes that occur in cancer patients receiving chemotherapy is analysed in this study. Peripheral smear and bone marrow aspiration  study was done in total of 82 cancer patients receiving different chemotherapy regime. The major haematological change observed was grade I–II anemia in 49% and grade III–IV in 13.4% of the cases. Bone marrow aspiration study revealed micronormoblastic maturation in 50%, both micro and macronormoblastic maturation in 18%,  megaloblastic change in 18% and 12% showed megakaryocyte hyperplasia with few dysmegakaryopoeitic cells.