Background: The 1^st year medical students are underneath enormous anxiety as they are facing a skilled medical course that wants entirety commitment and attentiveness. Objective: Therefore present study was designed to explore the attitude and response of medical students towards cadaveric Anatomy on first entry and after exposure to dissection. MATERIAL & METHOD: This observational study was performed on newly admitted 100 1^st year medical student, at the Department of Anatomy, C U Shah Medical College, Gujarat. All students were enrolled and their behaviour were observed at two time, one prior to dissection session, and second survey eight weeks after the first one .Standardized closed ended questionnaires prepared in suitable language, were used to collect relevant information from the students. RESULT: The encouraging feelings included an inquisitiveness and attention to learn about the organization of human body. Out of 100 students 85% students was mental awareness to study cadaver at the commencement of the course whereas 15 % not prepared. Various students were observed that impact of cadaveric dissection sway on routine activity, like horrifying thoughts (12%), anorexia (12% loss of appetite), anxiety and sleep disorder (8%), Nausea (25%), Vomiting (10%), Fainting (14%), Dizziness (12%), palpitation (5%), Sweating (14%), Sleep Disturbance(8%), Eye Irritation(40%) and Smell (32%) 10% medical students were no experience any symptoms during 1^st exposure of cadaveric dissection CONCLUSION: our study shows most of students reported their 1st exposure thrilling to dissection hall. There is long period since dissection is a part of medical anatomy, and still it is the most excellent road map of appreciate anatomy subject, it’s not substituted by any other tool and technique.