Background: The sciatic nerve (SN) originates from sacral plexus in the pelvis by union of the ventral branch of lumber and sacral vertebra L4, L5, S1, S2 and S3 sciatic nerve roots value. Sciatic   nerve palsy occurs after total hip replacement surgery in about 1 percent of cases. Objective: Therefore, the present study was designed to a cadaveric cram on higher division of sciatic nerve and its clinical significance. Materials and Methods: The present study was conducted in Department of anatomy, C. U. Shah Medical College, Surendranagar, Gujarat, over the epoch of five years. Total 25 cadavers (50 Lower limbs) were dissected as part of routine dissection for 1st year Medical students for Anatomy course. Results: In  the  present  study  of  25 cadavers,  Among them 46 specimens (92%) the sciatic nerve (SN) had a normal course after its exit below the piriformis and divided into TN and CPN at the  superior  angle  of  popliteal  fossa,  while  in  4  specimens  (8%) there was high division of SN within the pelvis in which the SN divided above the piriformis into TN & CPN, having a varied course. Conclusion: It concluded  the information  concerning the  variation  in  the  level  of  division  of  the sciatic nerve and  how  it  leaves the pelvis is vital  to avoid accidental injury to the nerve during several surgical events in the gluteal region.