Gastrointestinal Stromal Tumours (GISTs) are the most common gastrointestinal soft tissue malignancies. Most common site is stomach, followed by small intestine, esophagus ,colon ,rectum etc. The symptoms are mainly related to tumor size and site. Mutually exclusive mutations in Kit or PDGFRA receptor tyrosine kinase proteins observed in more than 80% of GISTs are central in sporadic GIST pathogenesis. In this study 50 cases of GISTs were evaluated . We tried to find out the relation of morphology and immunohistochemistry of GISTs, assessed the independent relation of the parameters which are included in this study with prognosis. We also tried to find out the effect of each factor independently on the clinical outcome.  We found that the prognosis and survival in GIST patients are dependent on pathological parameters – tumor size and mitotic count. No significant correlation was found between CD117 reactivity/site of origin of tumour with morphology or survival.