Fungal etiology is an uncommon (2% of all cases of endocarditis) and less frequent cause of endocarditis when vegetation grows on a native valve. Alcoholism, previous valvular heart disease or prosthetic valve replacement, immunodeficiency states, prolonged intra–venous hyper–alimentation, permanent pacemakers, and some congenital heart diseases can provide the predisposing factors .In this article we present a case of 60–year–old woman with mitral native valve endocarditis related to Candida parapsilosis which is a very rare cause of infective endocarditis and carries a high mortality risk. She presented to us with a history of intermeittent fever and fatigue since 20 days. Examination revealed digital clubbing and a mid–diastolic murmur in Mitral area.2 D–echo showed vegetations on the posterior mitral leaflet. All the three blood cultures grew Candida parapsilosis. Though surgery was indicated, prolonged treatment with intra–venous Amphotericin and Fluconazole showed regression of the vegetations as followed on 2D echocardiography. This is a rare case of candida endocarditis in a patient without any risk factors. Recommended treatment for fungal Endocarditis is combination of antifungal drugs and surgery but patient may respond to medical management alone.