Introduction: The spectrum of glomerular diseases varies significantly in different parts of the world and they are the leading cause of end–stage renal disease world wide. In the light of paucity of data from north eastern part of India, we studied the spectrum of glomerular diseases in a tertiary care centre at Shillong, Meghalaya and compared the spectrum in defined age group and sex.

Methods: All the kidney biopsies from January 2012 to June 2016 were analyzed with clinical, laboratory data including light microscopy and immunofluorescence study.

Result: A total of 192 renal biopsies were analyzed. 70 were males and 122 were females with a M:F ratio of 0.57:1. The age of patients ranged from 10 months – 65 years. The number of pediatric patients was 81 and adult patients were 111. Primary glomerular disease comprised 117 (60.93%) cases and secondary glomerular disease comprised 60 (31.25 %) cases. The most common presentation of patients was Nephrotic syndrome (52.6%). Minimal Change Disease (25.6%) and Focal Segmental Glomerulosclerosis (24.7%) were the most common types of primary whereas Lupus nephritis (80%) was the most common type of secondary glomerular disease.

Conclusion:  This study suggests that there is a need to incorporate the data from North East in the national biopsy registry to obtain accurate knowledge about incidence, spectrum, and distribution of biopsy proven glomerular disease in our racially heterogenous country.