A prospective study was planned to investigate the temporal relationship between disturbances in hormonal and biochemical profiles in burn patients and their prognostic significance in relation to ABSI and SOFA scoring systems. Fifty patients were divided into four groups depending upon the percentage body surface area involved. The biochemical markers for assessment of organ function were evaluated on day 1, day 4 and weekly thereafter till discharge. The total SOFA score and ABSI were calculated on the specified days and their prognostic significance compared using ROC curves. Results: The mean ± SD TBSA of all the patients was 37.7 ± 19.8 and 68% patients were admitted with inhalation burns. Mean percentage of full thickness burn in the four groups was 4.6 ± 3.9, 12.5 ± 7.9, 24.4 ± 8.2 and 36.2 ± 4.8, respectively. Nine deaths were reported and the per cent mortality increased with increasing TBSA. Significantly higher values of mean scores for SOFA–1, SOFA–4, SOFA_max and ABSI were observed for patients who fail to survive with respective scores of 6.66, 7.88, 11.0 and 11.33 compared to surviving patient with scores of 4.02, 3.26, 6.73 and 7.87 respectively (p<0.0001). SOFA max, ABSI, SOFA for day 1 and 4 were good predictors of mortality with SOFA max and ABSI having 100% sensitivity and 95.1% and 82.9% specificity, respectively. Conclusion: SOFA_max was the best predictor of mortality in burns patients. With the increase of 1 unit in SOFA score, the risk of death increases by 21.3%.