Background: Management of keloids is still controversial. Various treatment modalities are used, alone or in combination.

Objectives: To compare the efficacy of different treatment modalities (1) Conservative Topical Treatments (2) Liquid N₂ followed by Intralesional injection Kenacort (40mg/ml) (3) Intralesional injection 5–Fluorouracil (250mg/5ml) (4) CO2 laser

Methods: Total 80 patients with keloids and hypertrophic scars were randomly divided into four groups. The groups were compared for reduction in the size keloid, symptoms (pain and itching) and the incidence of adverse effects.

Results: Excellent response was seen  in 31(62%) was found to be more in group–2, who were treated with Liquid N2 followed by I/L inj. Triamcinolone (40mg/ml) as compared to other groups.

Conclusion:

Complete disappearance was more in group–2 as compared to Others.

Keloids of short duration responded better. In keloids/hypertrophic scars of <1/2 year duration 38.9% showed excellent response.

Complications were more observed in group–2 and group–3. Depigmentation in 25(50%) cases and Crusting and Ulceration in 11(22%) cases were observed in group–2. Whereas Ulceration and Crusting was found in 27(84.37%) in group–3. The incidence of recurrence was higher with CO 2 laser.