The most common cause of acute abdominal pain in the gastrointestinal system relates to an inflammatory process in stomach, small and large intestines and the pancreatic –biliary system.

              The symptoms are usually non–specific and are influenced by age of the patient, medication and co–existing diseases. For instance, intake of corticosteroids in an elderly individual with a perforation may end up being a Damocle’s Sword over a surgeon just into his practice.

              The reaction of the closed peritoneal cavity cleanly divided into various stages. Gastrointestinal perforation is the third most common cause for laparotomy as an emergency. With the advances in treatment of acid peptic disease, the incidence of peptic ulcer perforation decrease. The advent of laparoscopy and endoscopy has played a dramatic role both in diagnosis and management of gastro–intestinal perforation.