Background: Depression is a common psychological disorder and it may affect the life of infertile couples mainly females.

Objectives: To measure the magnitude of the depression, anxiety and stress and explore the association of these with demographic characteristics.

Methods: A descriptive cross–sectional study of 80 female subjects attending infertility clinic of GTB Hospital Delhi. DAS scale, a 42 item, self–reported questionnaire used to measure the negative emotional states of depression, anxiety and stress.

Results: 68.8%, 42.5%, and 61.3% of female subjects had experienced depression, anxiety and stress respectively. There is weak positive correlation between duration of infertility and depression among females but statistically significant (p=0.015).

Conclusion: As a high magnitude of psychological disorder came out among females of infertile couples. So there is need to identify and address this menace effectively. Routine screening and counselling should be associated with treatment of infertility.