Aim:To compare anatomical media clarity & visual outcomes between vitrectomy with silicone oil or without silicone oil in endophthalmitis.Methods: A retrospective study of 16 eyes of endophthalmitis was conducted. Group A includes Patients with pars plana vitrectomy (ppv) with silicone oil (SOI)& Group B includes patients with ppv without silicone oil. Patients were followed for 3 months postop.Results: Functionally useful vision of counting fingers 3 feet  was achieved in  6 patients in group A while 1  in group B. Media clarity grade I–II achieved in 6 patients  in group in A while only 1 patient  in group B. In group B persistence of inflammation found in 2 patients.Conclusion: Pars plana vitrectomy with silicone oil endotamponade is useful treatment modality which improves the anatomical and functional results in cases of endophthalmitis.