Background: India carries a huge diabetic population which is swelling further, medicine utilization studies might be one of the strategies to rationalize the medicine use in diabetics and to manage disease better in the community. Objectives: Our study mainly aimed at describing patterns of prescription of medicines to diabetics attending the OPD and also to assess patient’s compliance. Material and Methods: It was a prospective, observational and non–comparative study conducted at Medicine OPD in western part of New Delhi/NCR, India. The study was carried out in a minimum of 200 established type 2 diabetes patients, who visited the clinic for treatment during the time period of June 2016 to December 2016. The purpose and other details of the study was discussed with the patients. An oral consent was also taken from all the participating patients, prior inclusion in the study.  Results: A total of 200 diabetes mellitus patients were enrolled in the study, out of which 54% were males and 46% were females. The study revealed that Metformin was the most commonly prescribed single OHA in 25 (12.5%) patients. Among the drug combinations, 30 (15%) patients received glimepiride and metformin whereas metformin and sitagliptin combination was used in 35 (17.5%) patients. It was observed that only 160 (91.4%) of the patients showed good compliance (≥80% intake of recommended dosage regimen) with the metformin mono therapy. More compliance was observed in case of female (n = 86, 55.5%) as compared to male patients (n = 69, 44.5%). Conclusion: The study have shown that majority of the patients with type 2 diabetes in LYF Hospital/ Dr Gupta’s OPD were managed with Metformin mono therapy while the current OHA prescribing strategy did achieved satisfactory glycemic control on majority of the patient. Hence, combination therapies of Metformin with different OHAs were prescribed for proper glycemic control.