Background: This study is done to assess the knowledge, attitude and practice of Rational Pharmacotherapy (RPT) in medical students who have completed one year of clinical duties and studying Pharmacology.

Methods: 102 second MBBS students were given a 12point questionnaire about RPT. Result was expressed in percentage.

Results: The knowledge of RPT and the concept of “P drug” is present in about 90% of them. But in actual practice, only about 46% have the concept to properly follow the steps for selection of a rational drug for a disease condition. Around 84% understand the reasons for irrational drug use. Majority of them understand the difference between “P treatment” and “P drug”.

Conclusion: Though the knowledge of second year medical students regarding RPT is good, its practice needs improvement.