The aim of this study was to examine and assess research studies related to indoor air quality factors. This study also seeks to summarize and synthesize research findings to design a framework for healthy schools that can be utilized to improve the indoor air quality alongside associating respiratory signs and symptoms that emerge upon exposure to poor indoor air quality. Poor indoor air quality, even low levels of exposure, increases health risks among both students and teachers. Reducing air pollutants in schools and its health symptoms require knowledge of the consequences of poor indoor air quality if schools are to develop and implement effective interventions to design health schools. This integrative review targets research studies published from 2014 to 2017 that examined poor indoor air pollutants in a school setting and ways to optimize good indoor air quality. School buildings readily encounter high levels of varying indoor air pollutants. Air pollutants inclusive of CO₂, CO, formaldehyde, NO, O₃, PM, RH, SO₂, space and air volume, and VOCs contribute to the rise of adverse health outcomes in teachers and students. However, CO₂ is highly indicative of a need for interventions to minimize air pollutants and improve ventilation in schools. Ensuring good air quality in a school setting requires interventions to reduce the presence of air pollutants. Key recommendations focused on construction materials such as adhesives, carpeting, cleaning supplies used, composite wood–based products, and paints. Improved ventilation, quarterly HVAC maintenance, as well as heating and cooling systems with humidity control (50% RH) are also proposed.