Background/Aim: Diabetes mellitus (DM), a major global health problem. Diabetic retinopathy(DR) is one of those important complications and leading cause of blindness. Platelet volume is a marker of platelet activation and thought to be associated with these complications. In this study, we aimed to investigate the association between mean platelet volume and diabetics with and without retinopathy.

Material and Methods: In this study, 88 subjects were divided into two groups, group A is diabetics without retinopathy and group B is diabetics with retinopathy.

Results: A Significant difference was seen in HbA1c, FBS, PPBS when compared between two groups. MPV in group 1 was 7.79±0.48 and MPV in group 2 was 11.52±1.26 which was statistically significant (p <0.001).

Conclusion: Diabetics with retinopathy have higher MPV when compared to diabetics without retinopathy. We think that platelets may play a role in diabetic retinopathy