Carboxy terminal telopeptide of type 1 collagen (ICTP) is a 9KD fragment of Type 1 collagen, which is released into the extracellular fluid during the resorption of mature bone collagen,  its concentration in serum has been reported to correlate with bone resorption. Metformin a biguanide which is been widely used as antidiabetic agent has also shown anti osteoclastic effect. Aim: This research was undertaken to asses clinical and biochemical evaluation of efficacy of 1% metformin gel as an adjunct to SRP in chronic periodontitis. Methodology: 15 patients who are diagnosed with chronic periodontitis were included in the study. The clinical parameters like PI, MGI, BOP, PPD, CAL and GCF concentration of ICTP were evaluated at baseline and 3 months. The patients were subjected for full mouth SRP followed by 1% MF gel application subgingivally. Results: The findings suggest that short–term nonsurgical therapy and LDD of 1% Metformin resulted in an improvement in clinical signs of inflammation, along with subsequent decrease in GCF ICTP concentration. Reduction in GCF ICTP concentration was much better when there was multiple applications of Metformin Gel. Conclusion: 1% Metformin gel as an adjunct to SRP shows to decrease the PDL tissue destruction indicating an osteomodulatory effect.