The sex hormone which is secreted in minute quantities undergoes changes in levels according to different phases of menstrual cycle.  They play an important role in lipid metabolism, especially oestrogen. In our study 50 women of reproductive age group (15–49years) were recruited. Lipid profile was measured during all the four phases of menstrual cycle and it was found that HDL was highest in ovulatory phase, and LDL and total cholesterol was lowest in luteal phase, as compared to other phases of menstrual cycle. There are gender differences in plasma lipid   profiles, and that women are relatively protected against coronary heart disease (CHD) relative to their male counterparts. Furthermore, steroid hormones play an important role in the determination of   lipid profile concentrations. Based on these facts co–relation between different phases of menstrual cycle and lipid profile is established in our study.