Background:  The normal blood platelet count is 150,000–450,000/L .Many viral and bacterial infections result in thrombocytopenia and are the most common noniatrogenic cause of thrombocytopenia . A platelet count of approximately 5000–10,000 is required to maintain vascular integrity in the microcirculation.

Aim: To evaluate clinical profile, etiological profile and outcome of patients with febrile thrombocytopenia .

Materials and Methods: 219 patients, aged more than 15 years, presented with febrile thrombocytopenia were evaluated  for  clinical  manifestations, investigated in detail for etiological cause and treated symptomatically and specifically .

Results: Age and Sex distribution: Febrile thrombocytopenia affects all age groups but was more common in 15–45 years age group (82.95%) Male   outnumbered Female (80%) in present study. Etiology of disease: unidentified Viral fever (84.47%), Dengue (12.38%),Malaria (3.8%) were the common etiologies of febrile thrombocytopenia in present study. Severe bleeding manifestations were seen only 5.4% of patients with severe thrombocytopenia(platelet count less than 25,000).Mild to moderate bleeding manifestations were observed in 13%of patients.Platelet transfusions were given 25%of patients. Outcome: 98.15% patients had good recovery.

Conclusion: Undifferentiated viral fevers  , Dengue and Malaria   fever constitute majority of etiologies in cases of fever with thrombocytopenia in present study.Risk of bleeding increase when platelet count decreases below 20000.Out come is good in most of the patients.