National adult HIV prevalence in India is estimated at 0.26% and total number of people living with HIV in India is estimated at 21.17 lakhs in 2015. The signs and symptoms associated with HIV infection are useful for early detection of HIV. CD4 cell count is important measures of the efficacy of ART and subsequent immunological response.

Objectives: To know various symptoms/diseases and immune response to antiretroviral therapy.

Materials and Methods: This was a follow up study on the HIV/AIDS patients coming to ART centre in medical college. Data related to history, clinical examination and investigation were recorded including CD4 count on follow up visits and analyzed.

Results: 42% of HIV/AIDS patients were less than 40 years of age and 71% were males. Weight loss was most common (73%) associated symptoms/signs and tuberculosis was present in 30% cases. On applying repeated measure ANOVA test significant (p < 0.001) improvement was seen in CD4 count after starting Anti Retroviral therapy (ART).

Conclusion: Young adult males are prime victims of HIV/AIDS with associated tuberculosis in almost one third cases. Significant improvement was seen in CD4 cells count on starting Anti Retroviral therapy indicates improved immunity