Intestinal Gut flora and Mental health are compound structures. Recent studies show that gut microbiota and mental health are in bidirectional interaction and influence each other. Consequently, this era is witnessing an exponential growth in studies aiming to understand this interaction. Studies conclude that some microorganisms like Lactobacillus spp. employ vagus nerve for affecting mental health. Escherichia spp., Bacillus spp. etc. produce various neurometabolites or fermented products i.e. Dopamine, propionate etc. Others affect the HPA axis or cause inflammation affecting the CNS. Polysaccharides of intestinal microorganisms can also play a role by entering and affecting intestinal cells. These anomalies can be rectified by probiotic formulations or Fecal transplantation pills of beneficial species like Lactobacillus spp., Oscillibacter spp. etc. Dietary modifications are also helpful. The purpose of this article is to be a collection and interpretation of findings of prevalent and peripheral studies linking mood disorders with gut microbiota.