Nanomedicine and medical nanotechnology are considered to constitute new frontiers of medicine on a number of counts.  As with any such new scientific developments, significant moral and prudential concerns, which together come under ethical concerns overall, inevitably arise as regards the regulation of the implementation and use of these developments. The resultant need for ethical safeguards and regulations in nanomedicine gets compounded with the need for safeguards in microsurgical interventions given the prospect of combining the latter with, e.g., polymeric micelle–borne drug delivery.  The modes of addressing the need for combined ethical safeguards and regulations adopted here are those of reasoning from common morality relating to bioethics and of initiating reflective equilibrium, with consideration of the respective prospects and problems of nanomedicine (including nanotechnological implementation) and microsurgery as known to date, with examination of certain key transnational guidelines in medical ethics, but focusing on this particular combination of the two.