Papri (Holoptelea Integrifolia) is a popular traditional medicinal plant in India with a variety of chemical compounds that have been used in the treatment and prevention of Cancer of bladder, Viral, Acid gastritis, Intestinal Worms, topical ulcers, fever, Vomiting, Wounds healing, Diabetes and so on. There are various common vernacular names of the plant in India. The current review focuses on the recent research investigation on pharmacological action of papri plant, which showed antiviral,   antidiabetic, analgesic, antioxidant, antifungal, anti–inflammatory, CNS depressant, antitumor, anti–cancer activities and so on. The phytochemical analysis of Holoptelea Integrifolia (papri) has showed the presence and absence of steroids, phenols, proteins and so on. we have investigated some important compounds  like  epifriedlin , stigmaterol , β – sitosterol  and  betulinic acid which  have been  identified  and isolated from the plant species . The  Methanolic extract and petroleum ether extract  (100 & 200 mg/kg body weight) of  Holoptelea Integrifolia leaves and bark  has showed the Antifungal,  Anti–oxidant,  wound healing,  Anti–ulcer,  Anti–cancer,  Anti–helminthic,  Anti–diabetic,  CNS depressant, Heparo–protectives and Anti–bacterial properties which provide a base for further clinical approaches for this plant .