IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-6-12-13698 Original Research Paper Olfactory Meningioma: the Godfather of Cognitive impairment and behavioral changes– epidemiological features scrutinized Rami Dr. Makhamreh Basel Dr. Al manaseer Noor uddeen Dr. December 2017 6 12 01 02 ABSTRACT

 Impetus: Cognitive impairment and behavioral changes are suggestive of a frontal lobe pathology; this congregated with visual symptoms and anosmia should raise suspicion of olfactory meningioma. After surgical resection, recovery of the behavioral changes can be expected.

Objectives: In this review, we scrutinize the epidemiological features of olfactory meningioma diagnosed at a single referral center. Special emphasis has been dedicated to demographic features, clinical magnitudes, and risk factors related to the tumor treatment itself.

Patients and Methods: This retrospective review was carried out by reviewing medical records of patients diagnosed to have olfactory meningioma and treated at King Hussein Medical Center. Patients were retrieved from the electronic hospital database during a 12–year period (2004 to 2015). Demographic features; sex, age, size of tumor, resection extent, and post–operative history of radiation therapy, and recurrence were documented.

Preoperative radiological reports were used to confirm tumor location and size based on largest single dimension. Extent of resection was based on surgical operative notes and post–operative imaging.

Results: Sixty–seven patients developed olfactory meningioma. Female patients were 44–cases, with a median age of 49.61 years (range, 30–75years) at presentation. Clinically, the most frequent complaint was headache (62.68%) followed by mental changes (52.23%). visual impairment (31.34%),anosmia/hyposmia (26.86%).

Subtotal resection in 3–cases, recurrence noted in 4–patients, 1 mortality in early post–operative stage. 

 Conclusion: Olfactory groove meningioma is rare benign, slow–growing tumor, constituting only 2% of all primary intracranial tumors and 4–13% of all intracranial meningiomas. Clinical presentation is insidious and diagnosis often occur in the late stage. Cognitive impairment and behavioral changes is the cardinal presenting picture. The archetypical demographics of these tumors; female predominance, young age group 20–50 years. Olfactory meningiomas are treatable. After surgical resection, reversal of the changes in thought processes can be expected. Gross total resection is crucial for recurrence, adjuvant radiotherapy is still controversial.