Pancreaticoduodenectomy by Whipple’s resection is the procedure of choice  for tumors of the pancreas and periampullary region. Periampullary region includes ampullary , periampullary, pancreatic and duodenal anatomical sites. Resection surgery is indicated in any mass lesion at this site. A descriptive study was carried out for a period of 5 years from October 2013 to  october 2017 in the Department of pathology of our institute. 63 cases (both nonneoplastic masses and neoplastic ) subjected to Whipple’s operation out of a total 141 endoscopic biopsy proven and USG proven cases. Periampullary carcinoma was the predominant tumor. Our aim was to analyse the histopathologic features of the tumors included in the study.