Purpose:  To  study the prevalence of ophthalmic manifestations in connective tissue diseases, to monitor the progression .

Methods: Prospective, non  comparative , observational cohort study in tertiary care hospital, from  June 2014 to September 2015 , in 50   adult patients , with autoimmune connective tissue disease .

The demographic data, history regarding the disease, were recorded.

Ophthalmic examination included visual acuity, slit lamp examination, dry eye tests , dilated fundus examination ,intraocular pressure.

Results: Maximum patients (44%) were in the age group of 31–40 years. Rheumatoid arthritis was most common( 52%).The prevalence of ocular manifestations was 74%. 81.08% patients had anterior segment manifestations . 18.92% patients had posterior segment manifestations.  Only 4 patients had worsened at the end of the study.

Conclusions: In connective tissue diseases, prevalence of ocular manifestations in our study was 74%. Females were more commonly and aggressively affected . It is necessary to screen patients for ocular manifestations .