Progress in lipid modification therapy has resulted in a relative risk reduction of one–third in major vascular events but has not reduced cardiovascular disease mortality significantly. The study was conducted to investigate trend in the changes of lipid profile over a period of 5 years in healthy people of the different age group among. The mean age of the study cohort was 35.6 years. The mean serum cholesterol was 175.1±13.06mg%, HDL–58.35±8.05mg% TG–97.71±13.51mg%, LDL–98.92±19.47mg%. There was a significant increase of serum Cholesterol level, LDL & Triglyceride levels in the study II which was conducted after a gap of 5 years. The HDL cholesterol also showed a decrease across all age groups. There was a strong relationship between healthier lifestyle factors in individuals who maintained inception lipid profile.  Individuals who maintained desired lipid profiles  had a progressively higher prevalence of lower BMI (<25 kg/m²), moderate physical activity (30 min walking/day), and fruit and vegetable consumptions (5 servings/day).