Multifocal leiomyoma is a rare tumor in post renal transplant patients. We had one 25 years old young male patient– post renal transplant in 2008. He was evaluated in 2010 in view of abdominal pain. On ultrasound, thick wall septate necrotic area of liver was found. Histopathological examination of that area was suggestive of smooth muscle tumor of liver. In 2016, he was evaluated in Indraprastha Apollo hospital, New delhi in view of fever, cough and generalized weakness. On further evaluation, endobronchial mass was found in right bronchus intermedius and histology was suggestive of leiomyoma. He was managed conservatively as surgery was not possible in view of multifocal tumor. Patient improved symptomatically with conservative therapy. He was discharged and kept on follow up in OPD.