IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-7-1-13835 Original Research Paper A PROSPECTIVE STUDY OF ASSOCIATION BETWEEN SERUM TSH CONCENTRATION AND THYROID CANCER Dr. DR.K.RAJACHIDAMBARAM Dr. January 2018 7 1 01 02 ABSTRACT

 

More recently a few studies  have suggested that higher concentration of TSH, even within the normal range are  associated with subsequent diagnosis of thyroid cancer in patients with thyroid  nodules and even higher serum TSH levels have been found associated with advanced stages of thyroid cancer.

 

 

 

AIMS AND OBJECTIVES

 

l   To evaluate the utility of serum TSH estimation as a biochemical predictor of malignancy in suspicious thyroid nodules.

MATERIALAND METHODS:

 

PLACE: Chennai  Medical College and Hospital Research centre, Trichy

DURATION: November 2015 to June2017  which included a 6 month follow up.

NO.OF PATIENTS:50 patients with thyroid swellings suspicious of malignancy

TYPE OF STUDY:descriptive  analysis of clinical presentation and a correlation of TSH level and final histopathology were done.


OBSERVATION AND RESULTS:

 

.Mean preoperative TSH value in malignancy was higher compared to those with  benign disease. Incidence of malignancy increased with higher TSH values.

 

 

 

CONCLUSION:

 

There is a definite relationship between higher TSH levels and malignancy. TSH levels  could be used as predictor in clinically suspect malignant thyroid swelling with a benign  FNAC report. In such cases where TSH value is high, the FNAC can be repeated to confirm the diagnosis.