Introduction: Description of visual cortex and its blood supply requires a proper orientation of the calcarine sulcus.

Aim of the study: To study morphology of calcarine sulcus and compare the inter–individual and interhemispheric differences.

Materials and methods: The study was performed on 50 right and 50 left sided hemispheres of formalin fixed cadaveric brains which were collected from unclaimed and donated human cadavers from the Department of Anatomy and Forensic Medicine of Gauhati Medical College. All the specimens were photographed and data were recorded.

Results: Significant variations were found between right and left hemispheres in case of termination and length of the calcarine sulcus.  

Conclusion: In cases where the Calcarine sulcus is found to terminate before reaching occipital pole macular sparing may not be possible.