Inflammation is a part of the body’s immune response that involves the destruction of tissues and organs. It can be considered as part of the complex biological response of vascular tissues to harmful stimuli such as pathogens, damaged cells or irritants. The search for natural compounds and phytochemicals that are able to interfere with these mechanisms by preventing a prolonged inflammation could be useful for human health. Mollugo oppositifolia belongs to the family Molluginaceae. The present study was aimed to find the phytochemicals present and the evaluation of anti–inflammatory property of Mollugo oppositifolia extract using HRBC suspension method. The phytochemical analysis of the plant showed that the major constituents are the phenols, glycosides, tannins, terpenoids and steroids. The plant extract showed significant anti–inflammatory activity.