Depression is a state of low mood and aversion to activity that can affect a person‘s thoughts, behaviour, feelings and sense of well–being. It accounts 4.3% of total disability–adjusted life years. If current trends continue, it will become the leading cause of disease burden by the year 2030. Several previous studies have reported an association between low cholesterol level and major depressive disorder. Some studies demonstrated the relationship between dyslipidaemia and various psychiatric disorders. This open lable, prospective and observational study was conducted to evaluate the lipid profile of patient with major depressive disorder. A total of 810 newly diagnosed major depressive patients as per DSM–V criteria were divided into three groups i.e. group I, II & III consisting of 270 patients in each group were enrolled. Imipramine, sertraline and escitalopram as per schedule dose were given in these groups respectively. After completion of treatment, there was a significant increase in mean value of total cholesterol, triglycerides, HDL & LDL in all the three groups but these increase were within recommended range.

Conclusion: We conclude that a significant increase in mean value of total cholesterol, triglycerides, HDL & LDL in all the three groups but this increase were within recommended range. Evaluation of lipid profile in such type patient is essential to avoid any cardiovascular risk.