INTRODUCTION: The aim of this study was to evaluate the haematological profile of patients of sickle cell disease from tertiary care hospital in western Vidarbha. This study was carried out in the Department of Pathology between the period January 2014 to December 2015.

MATERIAL & METHODS: Haematological profile of 92 patients was studied during two year period which includes 47(51.08 %) males & 45(48.91%) females. Most patients were from low socioeconomic background. Study includes the haematological parameters of the symptomatic patients attending outpatient departments of Medicine, Paediatric & Gynaecology departments. Venous blood samples were collected in ethylele diamine tetraacetic acid bulb from the patients. Haemtological parameters were evaluated using Cellenium 19 auto analyser. Samples were also tested for sickling test, solubility test, Hb electrophoresis using Hydrasys 2 gel elecrtphoresis apparatus.

RESULT: Mean age of presentation in males was 16.65 & for females it was 18.08. Most of these patients were in the age group of 6 to 20 years. Average haemoglobin percentage was 9.32 gm%, MCV was 84.37 fl, MCH was 24.59 pg, MCHC was 29.16 gm%, HbF was 17.34%.

CONCLUSION: Sickle cell disease is one of the most common severe monogenic disorder in the world. In this study it was found that, these patients had moderate to severe anaemia with high value for foetal haemoglobin. Previous studies indicate variation in haematological parameters from region to region. Thus more imphasis is needed to encourage regionwise study of haematological profile in these patients.