The present study was undertaken to evaluate the in vitro antiurolithiatic activity of the medicinal plant Tridax procumbens. Both Methanolic and Aqueous extracts showed their maximum efficiencies in the dissolution of calcium oxalate crystals. Aqueous extract was even more efficient than methanolic extract in dissolution of calcium oxalate crystals. Our results have clearly indicated that the aqueous and methanolic extracts of Tridax procumbens were quite promising for further studies in this regard. In this study Cystone was used as standard drug.