Dental caries is the most prevalent and chronic oral disease affecting children and adults around the world. Irrespective of its high prevalence rate the proper aid of diagnosing high risk caries risk individuals are still lacking. Saliva can be used to study the physiological state of the body, having the potential to be used in the early detection and diagnosis of diseases. This is due to the abundant protein content in saliva, which can behave as biomarkers for diseases. There are various proteins candidate for a biomarker role on dental caries, namely, soluble immunoglobulin A, mucins, cystatin, statherins, defensins and CD14 aid in the early diagnosis of the disease susceptible individuals.