The impact of high prevalence of Chronic Kidney Disease (CKD) is now considered as a public health problem of epidemic proportion. It is also the leading factor for increased mortality every year Globally .  According to World Health Records 2002, the highest contribution of Kidney Disease is accounted as the Global burden issue. Diabetes Mellitus, Hypertension and Chronic Glomerul Nephritis are the traditional responsible causes for increased burden of renal failure in developed as well as developing countries. The intend of this review is to explore some unidentified causes of increase the kidney disease (CKDu) and CKD in certain geographical areas of the world due to environment or other  unknown factors.