Thrombocytopenia is considered a rare adverse effect observed post medication for tuberculosis (TB). Antituberculosis treatment or AKT is the preferred combination of medications prescribed to patients with TB. This is a case report of acute and severe thrombocytopenia due to re–administration of antituberculi medication AKT2. The patient, a 51 year old male, who “apparently” had completed an AKT1, 3 years ago, arrived at municipal hospital with clinical suspicion of Pulmonary TB. When the patient was administered the AKT2, he within 7 days, reported to the hospital with severe reactions possibly due to the medication. Considering the high incidence of TB in India and potentially equally high reoccurrence of TB, the use of AKT2 needs to be carefully considered.