Gram–negative bacilli form the frequent cause different types of infections. Klebsiella species are widely distributed in nature. They can cause pulmonary and extrapulmonary infections, including enteritis, meningitis, urinary tract infections, bacteremia, septicaemia, etc.  Present study aimed at evaluating the antimicrobial resistance pattern among the Klebsiella species from different clinical specimens. A total of 628 clinical isolates of Klebsiella species were obtained during the period of 3 years, most commonly from pus, sputum and urine samples. Most of the Klebsiella species were found sensitive to Imipenem and Cefepime while a high degree of resistance was observed towards most of the commonly used antibiotics like the third generation cephalosporins, aminoglycosides, ciprofloxacin, etc. The increasing clinical incidence of antibiotic–resistant bacteria is becoming a major global health care issue. For this reason, correct choice and use of antibiotics is the necessity of time.