Retrospective analysis of 60 post mastectomy breast cancer patients receiving hypofractionated radiotherapy 39 Gy / 13 fractions, 2.3 weeks at 3 Gy/fraction was done. Assessment was done for quality of life, local relapse, loco–regional relapse, distant relapse, acute and late radiation toxicities.

Results: Maximum number of patients was in age group 40–49 years, postmenopausal, invasive ductal carcinoma grade 2 and higher BMI .The locoregional relapse was 6.7% and distant relapse was 18.3%. Quality of life of patient was improved due to less overall treatment time, less hospital stay, less economical burden and acceptable toxicity.

Conclusion: The hypofractionated radiotherapy in mastectomy breast cancer patients can be safely, effectively and feasibly given utilizing its radiobiological effect.