Aim: The aim of the present study was to assess the efficacy of administrating   intrapocket Coenzyme Q10 as an adjunct to SRP in the treatment of chronic periodontitis.

Materials and methods: A total number of 10 patients (4 male and 6 female) in the age group of 20 – 55 years who were diagnosed with chronic periodontitis. The selected subjects were treated in two different quadrants randomly. Group I (Control quadrants ): those receiving only  SRP, Group II (Test quadrants): those receiving Perio QTM gel +

SRP.  Clinical parameters evaluated were plaque index (PI), gingival bleeding index (GI and  probing pocket depth (PPD), were measured at baseline , 3^rd week and 6^th weeks.

Results: In this  study there was significant decrease in the probing depth , plaque index, gingival index and gingival bleeding index in Groups  II (test quadrant)  as compared with Group I (control quadrant), study in all two groups as compared with baseline values, and there was  significant difference between the two groups during the study.  The P–value, 0.001, was statistically significant at the 3^rd week for the test groups. There is no difference in the results after a period of 6 weeks in both test and control quadrant.

Conclusion: This study showed significant reduction of  all clinical parameters when  Intrapocket Coenzyme Q10 is used as an adjunct to scaling and root planing than scaling and root planing alone. Therefore, CoQ10 along with scaling and root planing can prevent periodontitis by reducing gingival inflammation.